The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) enzyme is a ubiquitously expressed glycoprotein that is bound to the membrane of the endoplasmic reticulum (ER), but also projects an active C-terminal catalytic tail into the cytoplasm. It was concluded that reducing myeloid HMGCR may be a promising strategy to improve insulin resistance and hepatic steatosis in obesity. Expression of HMG-CoA reductase is low in most tissues, but it is markedly increased when muscle and other types of cells are exposed to statins. It is reactive with human, mouse and rat. View products. Images. HMGCR antibody LS-B16059 is an unconjugated rabbit polyclonal antibody to HMGCR (HMG-CoA Reductase) from human. Class II HLA allele DRB1*11:01 is strongly associated with the development of anti–HMG-CoA reductase autoantibodies, even in patients without known exposure to statins. Pathology. Tested on 20 paraffin-embedded human tissues. Labcorp COVID-19 Antibody Testing Available Nationwide ... 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase; Anti-HMGCOA; HMG-CoA Reductase; HMGCOA; Expected Turnaround Time. The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver … 2017;49(6):638–9. Labcorp COVID-19 Antibody Testing Available Nationwide Learn more >>>. Anti–HMG-CoA reductase autoantibodies have not been detected in statin-treated patients who do not have muscle disease. Compare HMG-CoA Reductase / HMGCR Antibody NBP1-91996 from Novus Biologicals on Biocompare.com Western Blot: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP2-61616] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human cell line MCF-7 Lane 3: Human cell line HepG2. Walk-ins are also welcome. Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). 2.5 - HMG-CoA réductase (enzyme-clé) LL 06: L’hydroxy-méthyl-glutaryl-coenzyme A réductase (HMG-CoA réductase) est l’enzyme du reticulum endoplasmique qui catalyse l’étape d’engagement de l’HMG-CoA vers la synthèse des prénoïdes et du cholestérol. Find yours today FIND ANTIBODIES. Immunohistochemistry-Paraffin: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP2-61616] - Staining of human skeletal muscle shows absence of immunoreactivity (negative control). Recently, auto-antibodies (AAbs) to the enzyme, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) was shown to be a MSA that was strongly associated with immune mediated … Autoantibodies against HMG-CoA reductase, the pharmacologic target of statins, are found predominantly in biopsy specimens from patients with necrotizing myopathy and much less frequently in specimens from patients with other types of myopathy. Anti-HMG-CoA reductase Antibody detects level of HMG-CoA reductase & has been published & validated for use in Immunoprecipitation, Western Blotting. Product General Protocols. reductase-associated autoimmune myopathy. Polyclonal HMG-CoA Reductase antibody, anti-HMG-CoA Reductase antibody, Hydroxymethylglutaryl-CoA reductase antibody: Cross Reactivity: Human, Mouse, Rat Applications: WB: Immunogen: HMG-CoA Reductase antibody was raised in Rabbit using synthetic peptide surrounding amino acid 830 of human HMG-CoA Reductase as the immunogen. Freeman MW et al. Autoantibodies against HMG-CoA reductase, the pharmacologic target of statins, are found predominantly in biopsy specimens from patients with necrotizing myopathy and much less frequently in specimens from patients with other types of myopathy. - Find MSDS or SDS, a COA, data sheets and more information. Als HMG-CoA-Reduktase- Inhibitoren haben sich die Statine durchgesetzt, die sich von dem Naturstoff Lovastatin ableiten, einer der Mevalonsäure verwandten Verbindung. IVIG and rituximab may be rituximab may be used in severe or refractory disease. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCR antibody [CL0260] (ab242315) Paraffin-embedded human liver cancer tissue stained for HMGCR using ab242315 at 1/50 dilution in … Testing schedules may vary. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. HMGCR Abs (3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase) are associated with necrotizing myopathy that is commonly related to statin exposure. By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. Copyright © 2020 ClinLabNavigator. Order anti-HMGCR Antikörper ABIN5526282. HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. Of particular interest is the recently reported hydroxy-3-methylglutaryl-coenzyme A reductase antibody (anti-HMGCoR). The LOINC® codes are copyright © 1994-2020, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. No. Western Blot: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP2-61616] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human cell line MCF-7 Lane 3: Human cell line HepG2 quantity: 100 ul (also 25 ul) price: 449 USD to the supplier. L'hydroxyméthylglutaryl-CoA réductase (HMG-CoA réductase, HMGCR) est une oxydoréductase intervenant dans la voie du mévalonate, dont elle régule l'intensité.La voie du mévalonate est une voie métabolique importante chez les eucaryotes supérieurs et certaines bactéries car elle produit les précurseurs du cholestérol et d'autres terpénoïdes. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density … IHC-plus™ HMG-CoA Reductase / HMGCR Antibody LS-B16059 is a pathologist validated IHC antibody Rabbit anti-Human HMG-CoA Reductase / HMGCR. Arthritis Care Res. 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoA reductase. Rat HMG-CoA(3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase) ELISA Kit Statement Manuals on the web are for your reference only, specifications are subject to the delivery manuals. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. In some cases, additional time should be HMG-CoA reductase antibody; Hmgcr antibody; Hydroxymethylglutaryl CoA reductase antibody; LDLCQ3 antibody; MGC103269 antibody; Red antibody; see all. All Rights Reserved. ​Labcorp's test menu provides a comprehensive list of specialty and general laboratory testing services. 2 million antibody products from 170 suppliers covering 27,000 proteins. Offering hospitals, researchers, clinical trials & occupational health logistics management, electronic interface & interchange, privacy, and QA. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen ; Submit a Review. HMG-CoA reductase antibody; Hmgcr antibody; Hydroxymethylglutaryl CoA reductase antibody; LDLCQ3 antibody; MGC103269 antibody; Red antibody; see all. Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGCR antibody [CL0260] (ab242315) Paraffin-embedded human liver cancer tissue stained for HMGCR using ab242315 at 1/50 dilution in … Treatment with HMG-CoA-reductase inhibitors significantly reduces the risk of cardiovascular morbidity and mortality, but may rarely cause serious adverse drug reactions (ADRs). The patient's genetic background, characteristic histologic patterns (immune-mediated necrotizing myopathy), and presence of anti-HMGCR antibodies define the syndrome. - Find MSDS or SDS, a COA… HMG-CoA Reductase Inhibitors (Statin) Prevents Retinal Neovascularization in a Model of Oxygen-Induced Retinopathy Manuela Bartoli , 2, 3 Mohamed Al-Shabrawey , 4 Mohamed Labazi , 5 M. Ali Behzadian , 5 Mohamed Istanboli , 5 Azza B. El-Remessy , 6 Robert W. Caldwell , 7 Dennis M. Marcus , 2 and Ruth B. Caldwell 1, 5 Anti-hydroxymethylglutaryl CoA reductase (HMGCR) myopathy is a subtype of myositis characterized by proximal muscle weakness, elevated serum creatine kinase (CK) levels, and autoantibodies recognizing HMGCR1. - Find MSDS or SDS, a COA… Method Name A short description of the method used to perform the test. Product General Protocols. HMG-CoA reductase antibody; Hmgcr antibody; Hydroxymethylglutaryl CoA reductase antibody; LDLCQ3 antibody; MGC103269 antibody; Red antibody; see all. HMGCoA réductase : Les myopathies nécrosantes auto-immunes constituent en fait un groupe de myopathie acquise idiopathique distinct des myosites à strictement parler. Anti-HMG-CoA reductase Antibody detects level of HMG-CoA reductase & has been published & validated for use in Immunoprecipitation, Western Blotting. It is found in the endoplasmic reticulum. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) is the rate-controlling enzyme (NADH-dependent, EC 1.1.1.88; NADPH-dependent, EC 1.1.1.34) of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. The most serious … HMG-CoA-reductase inhibitors and neuropathy: reports to the Netherlands Pharmacovigilance Centre Neth J Med. Western Blot: HMG-CoA Reductase/HMGCR Antibody (CL0259) [NBP2-61616] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human cell line MCF-7 Lane 3: Human cell line HepG2. Find general support by application … HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein via the LDL receptor as well as oxidized species of cholesterol. BioVision’s HMG-CoA Reductase Activity Assay Kit measures utilization of NADPH, which can be measured by the decrease of absorbance (OD 340 nm). Chemiluminescence Immunoassay (CIA) NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients. Direct toxicity usually occurs after a change in statin dose or when another drug, such as a cytochrome P-450 3A4 inhibitor, is prescribed. Background/Purpose: Statin use is associated with myalgias, muscle weakness and elevated muscle enzymes, but recent reports of a statin-induced immune-mediated necrotizing myopathy (IMNM) have been intriguing. Datasheet Shortlist; Aviva Systems Biology: OKEH02087: More Data OKEH02087 Human HMGCR Elisa … Anti–HMG-CoA reductase autoantibodies have not been detected in statin-treated patients who do not have muscle disease. Competitive inhibitors of the reductase induce the … Recently, a new myositis syndrome was described in association with antibodies directed against the pharmacologic target of statins, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR antibody). Human(3156) Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Statins can produce rhabdomyolysis through two distinct mechanisms; a direct toxic effect and the induction of autoantibodies to the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). - Find MSDS or SDS, a COA, data sheets and more information. Arthritis Rheum. M. Lavian, T. Mozaffar, N. et GoyalClinical Dermatomyositis Associated with Anti-HMG-CoA Reductase Antibody Positive Immune Mediated Necrotizing Myopathy: A Case Report (P2.125) Neurology, 88 (2017), p. 2. Enzyme-linked Immunosorbent Assay (ELISA). HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. While statins are an established risk factor for developing anti-HMGCR myopathy in older patients, some individuals develop this condition without a known statin … The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) enzyme is a ubiquitously expressed glycoprotein that is bound to the membrane of the endoplasmic reticulum (ER), but also projects an active C-terminal catalytic tail into the cytoplasm. Das entsprechende, in Bakterien aktive Enzym (EC 1.1.1.88) verwendet NADH als Cofactor. 0.5 mL (Note: This volume does not allow for repeat testing.). Compare HMG-CoA Reductase / HMGCR Antibody NBP1-91996 from Novus Biologicals on Biocompare.com This test was developed and its performance characteristics determined by LabCorp. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen ; Submit a Review. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested. Validated for ICC, IF, IHC and WB. Mammen AL, Statin-Associated Autoimmune Myopathy, N ENgl J Med 2016;374:664-9. Find general support by application … There are no reviews for HMG-CoA Reductase/HMGCR Antibody (NBP1-91996). Anti–HMG-CoA reductase autoantibodies have not been detected in statin-treated patients who do not have muscle disease. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Anti-HMG-CoA reductase Antibody detects level of HMG-CoA reductase & has been published & validated for use in Immunoprecipitation, Western Blotting. … GeneRIFs: Gene References Into Functions. It is the rate-limiting enzyme in the mevalonate pathway as it catalyzes the conversion of HMG CoA to mevalonate, which is a critical precursor protein in the synthesis of sterols such as cholesterols. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Binding of statin to HMG-CoA reductase may alter protein conformation, exposing cryptic epitopes to which the immune system is not tolerant, leading to autoimmunity. © 2020 Laboratory Corporation of America® Holdings. Unless the patient has only mild weakness, another immunosuppressive drug, , should be included at the outset. Antibody levels correlate with creatine kinase levels and strength in anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy. A paraneoplastic basis should be considered, according to age, sex, and other risk factors. Rabbit polyclonal antibody to HMGCR which is also known as HMG-CoA reductase whose expression can be detected in the blood and brain but it is majorly expressive in the suprapubic skin and adrenal gland. 14 - 21 days. HMG-CoA Reductase / HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase. Approximately 2 of every 100,000 patients taking statin medications develop an autoimmune myopathy that is characterized by muscle weakness, muscle-cell necrosis, and autoantibodies against 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

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